Available jobs at SEMC

Software Engineer at SEMC

The Simons Electron Microscopy Center (SEMC)  is one of the leading cryo electron microscopy centers in the world. Software and computing infrastructure is a critical component in a pipeline that enables collection, management and analysis of very large volumes of data. SEMC supports a national user community and is a “center of centers” including the following:

  1. The National Resource for Automated Molecular Microscopy (NRAMM) is a NIH  Biotechnology resource that focuses on technology development for cryoEM and is driven by biological projects
  2. The National Center for CryoEM Access and Training (NCCAT) is a NIH Common Fund  center that provides access and training to the national academic community
  3. The National Center for In-situ Tomographic Ultramicroscopy (NCITU) is a NIH Common Fund center to provides access and training for preparing in situ specimens for cryo electron tomography (cryoET)
  4. The Simons Machine Learning Center is a new initiative that will focus on developing machine learning methods to accelerate protein structure determination.

The SEMC computing group provides and supports the computing infrastructure essential to the collection and analysis of image data generated by 8 high-end electron microscopes and a range of supporting instruments. The group is responsible for overseeing and maintaining control software, data collection, data management, and the network of computers that enable the work of more than 1,000 users from the national community.

We are seeking a software engineer to build, extend and maintain software applications that electron microscope users and operators utilize to manage data collection and computation. The candidate must have experience in developing applications in an environment that is largely based on Linux, MySQL, PHP, Python and Django, as well as familiarity with UI/UX concepts.

The software engineer will be responsible for:

  • Building, maintaining and extending existing software applications
  • Collaborating with microscope operators on functionality and features
  • Working with system administrators to create front-end / back-end standards
  • Becoming familiar with Leginon, a system designed for automated collection of images from a transmission electron microscope
  • Rebuilding some applications to utilize new back-end system functionalities
  • Integrating with local infrastructure services consisting of OpenLDAP and MySQL
  • Maintaining source code in Git

To apply, visit our indeed posting here or email semcjobs [at] .



Research Associate and Scientist Positions

The New York Structural Biology Center (NYSBC) seeks an experienced microscopist to join the staff of the Simons Electron Microscopy Center (SEMC) ( The NYSBC is a shared center that supports state-of-the-art research in EM, NMR, and X-ray crystallography. The facilities will soon include twelve electron microscopes (including seven Titan Krios instruments) and a dual-beam scanning electron microscope equipped with a cryo stage. User projects focus on 3D reconstruction of biological assemblies using techniques including microED, single-particle reconstruction, tomography, and preparation of FIB milled lamellae.

To assist in these developments, NYSBC seeks an individual with experience in microscopy, image processing, and the ability to effectively communicate with scientists. Staff members will also have opportunities to pursue independent research projects, but the main focus is to support the research of affiliated investigators by maintaining and operating our scientific instruments. The individual should be capable of multitasking, should enjoy working with other people, should have a good working knowledge of microscopes and a strong research background.

Responsibilities include:

  • Operating and maintaining cryo-EM and related instrumentation.
  • Training facility users on the use of image processing applications and analysis.
  • Providing consultation to users on data analysis and interpretation of results.
  • Providing administrative and logistical support of day-to-day operations, including session scheduling, usage tracking and reporting, and materials acquisition.

Required qualifications: 

  • High school degree plus engineering and/or infield experience with 5-8 years of microscopy experience, OR Bachelor’s degree in science required plus 3-5 years of EM experience, OR Master’s degree in science and 1-3 years of cryo-EM experience, OR Ph.D. with cryoEM as the focus of your thesis research.
  • Firm understanding of the principles of transmission electron microscopy and demonstrated skill and experience in the operation of cryo-electron microscopes.
  • Strong communication skills (both verbal and written) are needed to interact professionally and effectively in the work environment such as the ability to read, write, comprehend, and discuss research materials.

Preferred qualifications:

  • Degree in structural biology, biophysics, biochemistry, computer science, engineering or closely related field.
  • Familiarity with biological structures at some level.
  • Ability to contribute to experimental design and assist with the analysis and interpretation of results.
  • Proven organizational and time management skills to successfully set priorities, meet established deadlines, and recognize new problems. 
  • Hands-on experience in maintenance and alignment of electron microscopes.
  • Experience with macromolecular model building in cryoEM reconstructions.
  • Experience in working in a Linux/UNIX environment and with cluster computing

To apply email semcjobs [at] .


Paid Internships and Technician Positions

The Simons Electron Microscopy Center ( at the New York Structural Biology Center is seeking to hire interns and technicians to add to its rapidly expanding group. We are looking for a bright and enthusiastic individual to help out with various tasks to keep the lab running. The most important requirements are a good attitude, ability to learn, ability to work independently, early riser, and willingness to do what needs to be done. Must be able to work in a multi-tasking environment where priorities may change often and be able to work well with others. Previous electron microscope experience is not required, but is a plus.

Requirements include

• a science degree (Associate degree or above),

• basic computer skills (comfortable with Linux environment and web interfaces) and

• comfortable around scientific instrumentation.


Qualified applicants should send a cover letter, CV, and names of three references.

To apply email semcjobs [at] .