NYSBC - New York Structural Biology Center

Simons Electron Microscopy Center

About the Simons Electron Microscopy Center

The Simons Electron Microscopy Center provides expertise and resources for understanding both molecular and cellular structures. Molecular structure determination is enabled by high-end transmission electron microscopes (TEMs), direct detection cameras, and computational support for single particle analysis. Cellular structure determination is enabled by tomographic reconstructions using the TEMs and a focused ion beam (FIB) scanning electron microscope (SEM). SEMC is supported by dues from member institutions as well as the Simons Foundation.

News and Events

SEMC Renovations Renovations
The Krios has arrived!

The Krios was delivered on Sunday 12/14/15, and it is currently being built! We hope to soon get the control room clear of boxes and restore it to a calm working space. However, there will then be some further disruption starting sometime in the next few weeks as we will be installing ducts to accommodate a new HVAC system and chillers. These systems will provide a stable environment for all of the TEM's and ensure that they are functioning at their highest possible performance.

Click here to view an updated Renovation schedule.

< New Publication: Architecture Formed by Large and Small Terminase Subunits Bacteriophage

Packaging of viral genomes inside empty procapsids is driven by a powerful ATP-hydrolyzing motor, formed in many double-stranded DNA viruses by a complex of a small terminase (S-terminase) subunit and a large terminase (L-terminase) subunit, transiently docked at the portal vertex during genome packaging. Despite recent progress in elucidating the structure of individual terminase subunits and their domains, little is known about the architecture of an assembled terminase complex.

Click here to read the full text

New Instrumentation: The Titan KriosTitan Krios
SEMC is delighted to announce that due to the continued generosity of the Simons Foundation, we will soon install an FEI Titan Krios microscope with a Falcon 2 camera (shortly to be upgraded to a Falcon 3). We are currently renovating space to house the instrument, and we anticipate that it will be ready for users at the end of the first quarter of 2016. The Titan Krios/Falcon 3 instrument will join the current lineup of instrumentation, including the four other transmission electron microscopes (JEOL 3200FSC/DE20, JEOL 2100F/K2, JEOL 1230/CCD, Tecnai F20/CCD), and a dual beam focused ion beam scanning electron microscope (Helios 650).

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Thursday 1/14
Palash Gangopadhyay
College of Optical Sciences
University of Arizona

Imaging Beyond Physical Dimensions.

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Thursday 11/19
Jack Johnson
Elden R. Strahm Emeritus Professor of Structural Virology

Ghost protocol: Seeing the invisible with cryoEM variance maps.

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