Simons Electron Microscopy Center
About the Simons Electron Microscopy Center
The Simons Electron Microscopy Center provides expertise and resources for understanding both molecular and cellular structures. Molecular structure determination is enabled by high-end transmission electron microscopes (TEMs), direct detection cameras, and computational support for single particle analysis. Cellular structure determination is enabled by tomographic reconstructions using the TEMs and a focused ion beam (FIB) scanning electron microscope (SEM). SEMC is supported by dues from member institutions as well as the Simons Foundation.
The Krios was delivered on Sunday 12/14/15, and it is currently being built! We hope to soon get the control room clear of boxes and restore it to a calm working space. However, there will then be some further disruption starting sometime in the next few weeks as we will be installing ducts to accommodate a new HVAC system and chillers. These systems will provide a stable environment for all of the TEM's and ensure that they are functioning at their highest possible performance.
Click here to view an updated Renovation schedule.
< New Publication: Architecture Formed by Large and Small Terminase Subunits
Packaging of viral genomes inside empty procapsids is driven by a powerful ATP-hydrolyzing motor, formed in many double-stranded DNA viruses by a complex of a small terminase (S-terminase) subunit and a large terminase (L-terminase) subunit, transiently docked at the portal vertex during genome packaging. Despite recent progress in elucidating the structure of individual terminase subunits and their domains, little is known about the architecture of an assembled terminase complex.
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College of Optical Sciences
University of Arizona
Imaging Beyond Physical Dimensions.
In this talk we will address synchronous multimodal atomic force microscopy imaging developed for mapping buried nanoscale objects as well as a multiphoton microscope that allows capture of 1, 2, and 3 photon 3D images simultaneously. We will also discuss a new noninvasive fiber optic magnetic field imaging technique that can map heart and brain functions in real time with high spatio-temporal resolution by synchronous multimodal imaging with MRI and EEG.
Elden R. Strahm Emeritus Professor of Structural Virology
Ghost protocol: Seeing the invisible with cryoEM variance maps.
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