JOB OPPORTUNITIES

Postdoctoral Researcher in Computational Proteomics

The Simons Electron Microscopy Center (SEMC) is a global leader in cryo electron microscopy (cryoEM) and provides expertise and resources for understanding both molecular and cellular structures. The facilities include 15 transmission electron microscopes and 3 dual-beam scanning electron microscopes and a dedicated high-resolution mass spectrometer. SEMC serves the nine members institutions of NYSBC, provides access and training to the national research community through the NIH National Center for CryoEM Access and Training (NCCAT), provides sample preparation and access and training for in situ cryoET through the NIH National Center for In-situ Tomographic Ultramicroscopy (NCITU), develops and disseminates new technologies through the Simons Resource for Automated Molecular Microscopy (SRAMM), and includes the Simons Machine Learning Center (SMLC) where a team of machine learning, computer vision, and computational biology experts are pushing the boundaries of machine learning and structural biology.

The New York Structural Biology Center (NYSBC) is a global leader in structural biology. The Center’s main facility comprises 50,000 square feet in Upper Manhattan and houses advanced instrumentation in Cryo-Electron Microscopy, Nuclear Magnetic Resonance Spectroscopy, and Protein Production. Its X-ray crystallographic facility is located at the National Synchrotron Light Source II at the Brookhaven National Laboratory. NYSBC is led by world leaders in structural biology and an outstanding staff of 50 researchers.

SEMC is seeking a highly motivated and talented Postdoctoral Researcher with a strong background in computer science and proteomics to join our interdisciplinary research team. This position offers an exciting opportunity to develop and apply cutting-edge computational methods for the analysis of cross-linking mass spectrometry (XL-MS) data, with the goal of integrating these insights with structural biology (cryo-EM) and single-cell analysis data to understand complex biological systems.

List of responsibilities:

The successful candidate will work on a project focused on developing novel computational algorithms and pipelines for the analysis of XL-MS data and its integration with cryo-EM and single-cell proteomics datasets. This includes: ·

  • Developing advanced algorithms for the identification and validation of cross-linked peptides from mass spectrometry datasets.
  • Creating computational strategies for the integration of XL-MS derived distance constraints with structural models obtained from cryo-EM.
  • Developing methods to utilize XL-MS data to inform and validate structural models of large macromolecular assemblies and dynamic protein complexes.
  • Exploring the application of XL-MS to understand protein interactions and conformational changes within the context of single-cell heterogeneity, potentially integrating with single-cell proteomics or transcriptomics data.
  • Applying machine learning and statistical approaches to improve the accuracy and efficiency of XL-MS data analysis and its integration with other modalities.
  • Developing software tools and resources for the broader scientific community to facilitate the integrated analysis of XL-MS, cryo-EM, and single-cell data.

The postdoc will be expected to:

  • Design and implement computational algorithms and pipelines specifically for XL-MS data analysis and its integration with structural and single-cell data.
  • Analyze large-scale XL-MS datasets, as well as potentially cryo-EM structures and single-cell omics data.
  • Develop and validate new computational tools and software for XL-MS data processing, analysis, visualization, and integration.
  • Collaborate effectively with experimental proteomics, structural biology (cryo-EM), and single-cell analysis researchers.
  • Present research findings at conferences and publish in peer-reviewed journals.
  • Contribute to the writing of grant proposals.
  • Potentially mentor graduate and undergraduate students

Required Qualifications and Experience:

  • A Ph.D. in Computer Science, Bioinformatics, Computational Biology, Chemistry, Biophysics, or a related field. Candidates with a Ph.D. in Proteomics or a related biological science with significant computational experience in mass spectrometry data analysis are also encouraged to apply.
  • Strong programming skills in one or more languages (e.g., Python, R, C++). Experience with the analysis of mass spectrometry data, with specific experience in proteomics data analysis being highly desirable.
  • Experience with cross-linking mass spectrometry data is a significant advantage.
  • Knowledge of statistical modeling, machine learning, and data mining techniques.
  • Excellent problem-solving, analytical, and critical thinking skills.
  • Strong written and oral communication skills, including the ability to present complex information clearly and concisely.
  • Ability to work independently and as part of a collaborative team.

Preferred Qualifications and Experience:

  • A track record of authoring peer reviewed publications.
  • Familiarity with protein structure, interactions, and structural biology concepts is highly desirable.
  • Experience with cryo-EM data or structural modeling is a plus. Experience with single-cell omics data analysis (e.g., scRNA-seq, scProteomics) is beneficial.
  • Experience with software development and the creation of user-friendly tools is a plus.

Contact for Inquiries and Applications:

  • Alex de Marco alex@nysbc.org
  • Apply on Indeed

E-Verify Statement:

We participate in E-Verify, an electronic employment verification program operated by the Department of Homeland Security in partnership with the Social Security Administration, to verify the employment eligibility of newly hired employees.

Job Types: Full-time, Contract

Benefits:

  • 401(k) matching
  • Dental insurance
  • Flexible spending account
  • Health insurance
  • Paid time off
  • Retirement plan
  • Vision insurance

Schedule:

  • 8 hour shift
  • Monday to Friday

Ability to Commute:

  • New York, NY 10027 (Required)

Ability to Relocate:

  • New York, NY 10027: Relocate before starting work (Required)

Work Location: In person

Structural Biology Research Associate

The Simons Electron Microscopy Center (SEMC) is a global leader in cryo electron microscopy (cryoEM) and provides expertise and resources for understanding both molecular and cellular structures. The facilities include 15 transmission electron microscopes and 3 dual-beam scanning electron microscopes. SEMC serves the nine members institutions of NYSBC, provides access and training to the national research community through the NIH National Center for CryoEM Access and Training (NCCAT), provides sample preparation and access and training for in situ cryoET through the NIH National Center for In-situ Tomographic Ultramicroscopy (NCITU), develops and disseminates new technologies through the Simons Resource for Automated Molecular Microscopy (SRAMM), and includes the Simons Machine Learning Center (SMLC) where a team of machine learning, computer vision, and computational biology experts are pushing the boundaries of machine learning and structural biology.The New York Structural Biology Center (NYSBC) is a global leader in structural biology. The Center’s main facility comprises 50,000 square feet in Upper Manhattan and houses advanced instrumentation in Cryo-Electron Microscopy, Nuclear Magnetic Resonance Spectroscopy, and Protein Production. Its X-ray crystallographic facility is located at the National Synchrotron Light Source II at the Brookhaven National Laboratory. NYSBC is led by world leaders in structural biology and an outstanding staff of 50 researchers.SEMC is seeking a research associate to add to its electron microscopy operations team. The main duties of this position involve service (sample preparation and data collection using the scientific equipment), and training our users to make use of instrumentation at the Center. Applicants must be able to work in a multi-tasking environment where priorities may change often and be able to work well with others. We currently operate a cryoEM sample preparation laboratory and several EM suites with 9 Titan Krioses, 4 Glacioses, 2 side-entry TEMs, and 3 cryo-FIB/SEMs.

Responsibilities:

  • Day-to-day instrument operation, including image acquisition and microscope maintenance.
  • Training facility users in cryoEM technology.
  • Providing logistical support for day-to-day operations for users of the Center.
  • Providing consultation to users on data and results obtained at the Center.

Required Qualifications and Experience:

  • A science degree (Bachelors degree or above),
  • Strong communication skills (both verbal and written) are needed to interact professionally and effectively in the work environment such as the ability to read, write, comprehend, and discuss research materials,
  • Familiar working in a laboratory environment,
  • Comfortable around scientific instrumentation
  • Scientific computing skills (comfortable with Linux environment and web interfaces).

Preferred qualifications:

  • Degree in biology, structural biology, biophysics, biochemistry, or closely related field.
  • Familiarity with biological structures at some level or laboratory experience with biological macromolecules.
  • Ability to contribute to experimental design and assist with the analysis and interpretation of results
  • Proven organizational and time management skills to successfully set priorities meet established deadlines and recognize new problems.
  • Able to communicate with customers for cross-training and answering questions about SOPs, and
  • Exposure to high-end instrumentation and electron microscopes.

E-Verify Statement:

We participate in E-Verify, an electronic employment verification program operated by the Department of Homeland Security in partnership with the Social Security Administration, to verify the employment eligibility of newly hired employees.Contact for Inquiries and Applications:

  • Elina Kopylov ekopylov@nysbc.org
  • Ed Eng eeng@nysbc.org
  • Apply on Indeed

Benefits:

  • Dental insurance
  • Flexible spending account
  • Health insurance
  • Life insurance
  • Paid time off
  • Parental leave
  • Retirement plan
  • Vision insurance

Schedule:

  • 8 hour shift
  • Monday to Friday

Ability to Commute:

  • New York, NY 10027 (Required)

Ability to Relocate:

  • New York, NY 10027: Relocate before starting work (Required)

Work Location: In person

Staff Electron Microscopist Position

The Simons Electron Microscopy Center (SEMC) is a global leader in cryo electron microscopy (cryoEM) and provides expertise and resources for understanding both molecular and cellular structures. The facilities include 15 transmission electron microscopes and 3 dual-beam scanning electron microscopes. SEMC serves the nine members institutions of NYSBC, provides access and training to the national research community through the NIH National Center for CryoEM Access and Training (NCCAT), provides sample preparation and access and training for in situ cryoET through the NIH National Center for In-situ Tomographic Ultramicroscopy (NCITU), develops and disseminates new technologies through the Simons Resource for Automated Molecular Microscopy (SRAMM), and includes the Simons Machine Learning Center (SMLC) where a team of machine learning, computer vision, and computational biology experts are pushing the boundaries of machine learning and structural biology.The New York Structural Biology Center (NYSBC) is a global leader in structural biology. The Center’s main facility comprises 50,000 square feet in Upper Manhattan and houses advanced instrumentation in Cryo-Electron Microscopy, Nuclear Magnetic Resonance Spectroscopy, and Protein Production. Its X-ray crystallographic facility is located at the National Synchrotron Light Source II at the Brookhaven National Laboratory. NYSBC is led by world leaders in structural biology and an outstanding staff of 50 researchers.SEMC is seeking a staff microscopist to add to its electron microscopy operations team. The main duties of this position involve service and assisting our external users make use of the scientific equipment at the Center. Applicants must be able to work in a multi-tasking environment where priorities may change often and be able to work well with others. We currently operate a cryoEM sample preparation laboratory and several EM suites with 9 Titan Krios TEMs, 4 Glacios TEMs, 2 side-entry TEMs, and 3 cryo-FIB/SEMs. Along with a CV please include a cover letter with at least 3 references.

Responsibilities:

  • Day-to-day instrument operation, including image acquisition and microscope maintenance.
  • Training facility users in cryoEM technology.
  • Providing logistical support for day-to-day operations for users of the center.
  • Providing consultation to users on data and results obtained at the center.

Required Qualifications and Experience:

  • A science degree (Bachelors degree with at least 3 years of in-field experience; Masters degree with at least 2 years of in-field experience; or Doctorate degree),
  • Strong communication skills (both verbal and written) are needed to interact professionally and effectively in the work environment such as the ability to read, write, comprehend, and discuss research materials,
  • Familiar working in a laboratory environment,
  • Comfortable around scientific instrumentation, and
  • Scientific computing skills (comfortable with Linux environment and web interfaces).

Preferred qualifications:

  • Degree in biology, structural biology, biophysics, biochemistry, computer science, engineering, or closely related field.
  • Familiarity with biological structures at some level.
  • Ability to contribute to experimental design and assist with the analysis and interpretation of results
  • Proven organizational and time management skills to successfully set priorities meet established deadlines and recognize new problems.
  • Hands-on experience in maintenance and alignment of electron microscopes.
  • Experience with macromolecular model building in cryoEM density maps.
  • Experience in working in a Linux/UNIX environment and with cluster computing.

E-Verify Statement:

We participate in E-Verify, an electronic employment verification program operated by the Department of Homeland Security in partnership with the Social Security Administration, to verify the employment eligibility of newly hired employees.Contact for Inquiries and Applications:

  • Elina Kopylov ekopylov@nysbc.org
  • Ed Eng eeng@nysbc.org
  • Apply on Indeed

Job Types: Full-time, Contract

Benefits:

  • Dental insurance
  • Flexible spending account
  • Health insurance
  • Life insurance
  • Paid time off
  • Parental leave
  • Retirement plan
  • Vision insurance

Schedule:

  • 8 hour shift
  • Monday to Friday

Ability to Commute:

  • New York, NY 10027 (Required)

Ability to Relocate:

  • New York, NY 10027: Relocate before starting work (Required)

Work Location: In person

Lab Technician

The Simons Electron Microscopy Center (semc.nysbc.org) at the New York Structural Biology Center is seeking to hire a laboratory technician to add to its expanding group. We are looking for a bright and enthusiastic individual to help out with various tasks to keep the lab running and operate scientific instrumentation. Most important requirements are a good attitude, ability to learn, able to work independently, early riser and willingness to do what needs to be done. Must be able to work in a fast paced, multi-tasking environment where priorities may change often and quickly and be able to work well with others. Previous electron microscope experience is not required, but is a plus.

Responsibilities include:

  • Assist users with operating scientific instrumentation at the facility,
  • Upkeep of the cryoEM sample preparation laboratory,
  • Room temperature and cryo sample preparation for electron microscopy,
  • Operation of screening transmission electron microscopes, and
  • Administration, scheduling and email communications to users of the facility.

Required qualifications:

  • a science degree (Associate degree or above),
  • awareness of structural biology and related fields
  • familiar working in a laboratory environment
  • comfortable around scientific instrumentation
  • basic computer skills (comfortable with Linux environment and web interfaces)

Preferred qualifications:

  • laboratory experience with biological macromolecules (protein, RNA, DNA) at some level
  • organizational and time management skills,
  • able to communicate with customers for cross-training and answering questions about SOPs
  • exposure to high-end instrumentation and electron microscopes

Benefits:

  • 403(B) Retirement plan with employer contribution
  • Health insurance
  • Dental insurance
  • Vision insurance (with contribution)
  • Flexible spending account
  • Paid time off

Job Type: Full-time

To apply, please send a cover letter, curriculum vitae, and the names of three references. For additional queries email semcjobs