JOB OPPORTUNITIES

The New York Structural Biology Center (NYSBC) seeks an electron microscopist to join the staff of the Simons Electron Microscopy Center (SEMC) (semc.nysbc.org). The facilities include 12 transmission electron microscopes (with seven Titan Krios and two Glacios instruments), two dual-beam scanning electron microscopes each equipped with a cryo stage, and more microscopes on the way. This individual will primarily be a cryoEM specialist who will assist users of the facility to carry out service experiments. The individual should be capable of multitasking, should enjoy working with other people, and should have a good working knowledge of electron microscopes and a strong research background. Good communication skills are essential. Salary commensurate with experience.

Responsibilities include:

• Day-to-day instrument operation, including image acquisition and microscope maintenance.
• Training facility users in cryoEM technology.
• Providing logistical support for day-to-day operations for users of the center.
• Providing consultation to users on data and results obtained at the center.

Required qualifications:

• Bachelor’s degree in science required plus 3-5 years of cryoEM experience, OR Master’s degree in science and 1-2 years of cryoEM experience, OR PhD with cryoEM as the focus of thesis research.
• Firm understanding of the principles of transmission electron microscopy and demonstrated skill and experience in the operation of cryo-electron microscopes.
• Strong communication skills (both verbal and written) are needed to interact professionally and effectively in the work environment such as the ability to read, write, comprehend, and discuss research materials.

Preferred qualifications:

• Degree in structural biology, biophysics, biochemistry, computer science, engineering, or closely related field.
• Familiarity with biological structures at some level.
• Ability to contribute to experimental design and assist with the analysis and interpretation of results
• Proven organizational and time management skills to successfully set priorities meet established deadlines and recognize new problems.
• Hands-on experience in maintenance and alignment of electron microscopes.
• Experience with macromolecular model building in cryoEM density maps.
• Experience in working in a Linux/UNIX environment and with cluster computing.

Benefits:

• 403(B) Retirement plan with employer contribution
• Health insurance
• Dental insurance
• Vision insurance (with contribution)
• Flexible spending account
• Paid time off

Job Type: Full-time

Salary: $45,000.00 – $93,500.00 per year

To apply, please send a cover letter, curriculum vitae, and the names of three references. For additional queries email semcjobs

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The Simons Electron Microscopy Center (semc.nysbc.org) at the New York Structural Biology Center is seeking to hire a laboratory technician to add to its expanding group. We are looking for a bright and enthusiastic individual to help out with various tasks to keep the lab running and operate scientific instrumentation. Most important requirements are a good attitude, ability to learn, able to work independently, early riser and willingness to do what needs to be done. Must be able to work in a fast paced, multi-tasking environment where priorities may change often and quickly and be able to work well with others. Previous electron microscope experience is not required, but is a plus.

Responsibilities include:

• Assist users with operating scientific instrumentation at the facility,
• Upkeep of the cryoEM sample preparation laboratory,
• Room temperature and cryo sample preparation for electron microscopy,
• Operation of screening transmission electron microscopes, and
• Administration, scheduling and email communications to users of the facility.

Required qualifications:

• a science degree (Associate degree or above),
• awareness of structural biology and related fields
• familiar working in a laboratory environment
• comfortable around scientific instrumentation
• basic computer skills (comfortable with Linux environment and web interfaces)

Preferred qualifications:

• laboratory experience with biological macromolecules (protein, RNA, DNA) at some level
• organizational and time management skills,
• able to communicate with customers for cross-training and answering questions about SOPs
• exposure to high-end instrumentation and electron microscopes

Benefits:

• 403(B) Retirement plan with employer contribution
• Health insurance
• Dental insurance
• Vision insurance (with contribution)
• Flexible spending account
• Paid time off

Job Type: Full-time

Salary: $45,000.00 – $60,000.00 per year

To apply, please send a cover letter, curriculum vitae, and the names of three references. For additional queries email semcjobs

The New York Structural Biology Center (NYSBC), Rockefeller University, and the Center for Computational Biology (CCB) of the Simons Foundation’s Flatiron Institute invite applications for a postdoctoral position in RNA structural biology to be part of an interdisciplinary collaboration between structural and computational biologists.

This inter-institutional collaboration aims to advance the understanding of fundamental and historically challenging biological processes by developing theory, computational and experimental frameworks for analyzing challenging biomolecules using structural and molecular biology techniques.

The successful candidate will join the vibrant and collaborative research communities at NYSBC, Rockefeller University, and CCB, which collectively comprises one of the largest cryoEM communities in the world, with more than 100 research and data scientists at all career stages – graduate students through senior scientists – as well as visiting scientists, guest researchers, graduate students, interns, and administrative support staff. NYSBC will be the employer of record.

Minimum Qualifications:

• Ph.D. or equivalent degree in biochemistry, biophysics, structural biology, molecular biology, or a related field.
• Strong scientific record, excellent communication skills, self-motivated, and can work independently and as part of a team.
• Preferred Qualifications:
• A strong background in biochemistry, biophysics, and/or structural biology.
• Expertise in experimental molecular biology techniques (e.g., PCR, gel electrophoresis, in-vitro transcription, etc.).
• Prior knowledge in RNA biology.
• Experience with cryo-EM, X-ray crystallography, single-molecule biophysics, and/or computational biology.

What We Offer:

• Working as part of a highly collaborative, enthusiastic, and diverse team of structural and computational biologists.
• Supportive mentoring.
• A vibrant scientific community with weekly local meetings at the NYSBC and Flatiron Institute.
• Annual attendance at national and international research conferences.

Benefits:

• 403(B) Retirement plan with employer contribution
• Health insurance
• Dental insurance
• Vision insurance (with contribution)
• Flexible spending account
• Paid time off

Job Type: Full-time

Salary Range: $75,000/yr – $87,000/yr depending on experience.

To apply, please send a cover letter, curriculum vitae, and the names of three references. For additional queries email semcjobs

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The New York Structural Biology Center (NYSBC) is seeking an expert scientist in Proteomics and Mass Spectrometry. The individual will be working in tight collaboration with the Simons Electron Microscopy Center (which is among the largest cryo-Electron microscopy centers in the world) and developing methods for structural and ultrasensitive proteomics. Come and join a buzzing community working with the latest technology in structural biology in the center of New York. The team is an interdisciplinary community of experts in microscopy, engineering, image processing, software development, and cell and structural biology.

The focus of this position will be predominantly on method development; therefore, a good knowledge of Liquid Chromatography systems will be critical for success. All the experiments will be done in a framework that validates the data obtained through in situ cryo-electron tomography (visual proteomics). Accordingly, proficiency in data analyses for proteomics is required, but the capacity to develop new pipelines will be a significant plus. This position will be extremely interdisciplinary, therefore curiosity and willingness to learn new methods and approach neighboring fields are essential for success.

Responsibilities include:

• Performing research in the field of proteomics.
• Maintaining and setting up the LC/MS.
• Data analysis.
• Development of novel methods for sample preparation, data acquisition, and analyses.

Required qualifications:

• PhD in Biochemistry, Cell Biology, Structural Biology, or a related field.
• A minimum of 3 years of experience in Proteomics.
• Knowledge of LC/MS systems and basic maintenance.
• Demonstrated knowledge of proteomics data analyses.
• Strong communication skills (both verbal and written) are needed to interact professionally and effectively in the work environment.
• Experience and willingness to teach and train younger members of the team.
• Mastery of bioinformatics tools for RNAseq and other bio-analytics is a plus.
• Proven organizational and time management skills to successfully set priorities, meet established deadlines and recognize new problems.
• Experience in working with large datasets.

Preferred qualifications:

• Experience on ThermoFisher LC/MS
• Experience in cryo-Electron Microscopy is a plus.
• Experience in working in a Linux/UNIX environment and with cluster computing.

Benefits:

• 403(B) Retirement plan with employer contribution
• Health insurance
• Dental insurance
• Vision insurance (with contribution)
• Flexible spending account
• Paid time off

Job Types: Full-time, Contract

Salary: $80,000.00 – $110,000.00 per year

To apply, please send a cover letter, curriculum vitae, and the names of three references. For additional queries email semcjobs

Apply Now on Indeed

SEMC is seeking an experienced image analyst to boost its Cryo-Electron Tomography and Volume Electron Microscopy processing pipelines. This position will implement fully automated workflows for Cryo-Correlative Light and Electron Microscopy (cryoCLEM) and in situ structural biology. The post will be expected to collaborate within the lab as well as with the local New York community. We currently operate 7 Titan Krioses, 3 Glacioses, and soon to be 3 cryo-FIB/SEMs (Aquilos 2, Hydra, and Arctis) microscopes.

Responsibilities:

• Support data processing workflows for Subtomogram Averaging.
• Support automated and supervised data labeling (tomography, particle picking, and segmentation).
• Develop image processing tools to complement the methods developed in the Center.
• Implement new and existing data workflows from the Microscope to data interpretation.
• Engage in scientific presentations and consult with the local New York cryoEM community.
• Assist scientific training during the international workshops organized by the NYSBC.

Minimum Qualifications:

• PhD in structural biology, cell biology, physics, chemistry, data science, or related field
• Proven expertise in image analysis using published and custom methods and workflow
• Experience working withing HPC environments
• Programming experience in Python
• Experience in Machine Learning workflows
• Able to operate independently
• Good organizational and communication skills
• Team player

Preferred Qualifications:

• Experience programming in C++, Java, JavaScript, SQL, PHP, HTML
• Experience image acquisition in Electron Microscopy
• Experience in tomogram and sub-tomogram processing

Benefits:

• 403(B) Retirement plan with employer contribution
• Health insurance
• Dental insurance
• Vision insurance (with contribution)
• Flexible spending account
• Paid time off

Job Type: Full-time

Salary: $90,000.00 – $115,000.00 per year

To apply, please send a cover letter, curriculum vitae, and the names of three references. For additional queries email semcjobs

Apply Now on Indeed